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KMID : 0043320130360030353
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Archives of Pharmacal Research
2013 Volume.36 No. 3 p.353 ~ p.358
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miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells
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Yoo Jung-Ki
Jung Ho-Yong
Kim Chang-Hyun
Son Woo-Sung
Kim Jin-Kyeoung
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Abstract
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MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate gene expression through binding to 3′ untranslated region. We identified and characterized the novel miRNA, miR-7641, in human mesenchymal stem cells. The expression of miR-7641 was downregulated during differentiation from human embryonic stem cells to endothelial cells. The CXCL1, a member of the CXC chemokine family, is known as promoting neovascularization by binding G-protein coupled receptors and is related to endothelial cells biogenesis such as angiogenesis, and it was predicted as target gene of miR-7641 by computerized analysis and the luciferase reporter assay. The miR-7641 significantly suppressed CXCL1 of transcriptional and post-translational levels. These data suggest that miR-7641 might be related with differentiation of human endothelial cells.
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KEYWORD
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MicroRNA, Human ES cells, Endothelial differentiation, CXCL1
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